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Identification of Plasmodesmal Localization Sequences in Proteins In Planta.

14 hours 51 min ago

Identification of Plasmodesmal Localization Sequences in Proteins In Planta.

J Vis Exp. 2017 Aug 15;(126):

Authors: Yuan C, Lazarowitz SG, Citovsky V

Abstract
Plasmodesmata (Pd) are cell-to-cell connections that function as gateways through which small and large molecules are transported between plant cells. Whereas Pd transport of small molecules, such as ions and water, is presumed to occur passively, cell-to-cell transport of biological macromolecules, such proteins, most likely occurs via an active mechanism that involves specific targeting signals on the transported molecule. The scarcity of identified plasmodesmata (Pd) localization signals (PLSs) has severely restricted the understanding of protein-sorting pathways involved in plant cell-to-cell macromolecular transport and communication. From a wealth of plant endogenous and viral proteins known to traffic through Pd, only three PLSs have been reported to date, all of them from endogenous plant proteins. Thus, it is important to develop a reliable and systematic experimental strategy to identify a functional PLS sequence, that is both necessary and sufficient for Pd targeting, directly in the living plant cells. Here, we describe one such strategy using as a paradigm the cell-to-cell movement protein (MP) of the Tobacco mosaic virus (TMV). These experiments, that identified and characterized the first plant viral PLS, can be adapted for discovery of PLS sequences in most Pd-targeted proteins.

PMID: 28829412 [PubMed - in process]

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Perspective On Health Seeking Behavior Of Patients With Oropharyngeal Cancers From A Pakistani Background.

14 hours 51 min ago
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Perspective On Health Seeking Behavior Of Patients With Oropharyngeal Cancers From A Pakistani Background.

J Ayub Med Coll Abbottabad. 2016 Oct-Dec;28(4):830-831

Authors: Shoaib M, Ahmed SA, Waqar SM, Abbasi Z, Yusuf FH

Abstract
Oropharyngeal cancers are the most common cancers of head neck region, they are placed amongst the top ten malignancies globally and around 40% of all the cancers in South and South East Asia. Patient's personal behaviour impacts causality more than the environmental factors in the pathology and prognosis of this particular cancer. In our country risk factors are based on poor infrastructure of the health care system, illiteracy, poor socioeconomic status, Betel nut and quid, smokeless and smoke tobacco. We recommend that an active precautionary approach is required to restrict the rising incidence in the oral cancers, particularly due to culturally related risk habits and reluctance to seek early healthcare amongst our people. Primary prevention is the need of time.

PMID: 28828766 [PubMed - in process]

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Smoking Cessation Pharmacotherapy Among Smokers Hospitalized for Coronary Heart Disease.

14 hours 51 min ago
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Smoking Cessation Pharmacotherapy Among Smokers Hospitalized for Coronary Heart Disease.

JAMA Intern Med. 2017 Aug 21;:

Authors: Pack QR, Priya A, Lagu TC, Pekow PS, Rigotti NA, Lindenauer PK

PMID: 28828485 [PubMed - as supplied by publisher]

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Small airway imaging phenotypes in biomass- and tobacco smoke-exposed patients with COPD.

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Small airway imaging phenotypes in biomass- and tobacco smoke-exposed patients with COPD.

ERJ Open Res. 2017 Apr;3(2):

Authors: Fernandes L, Gulati N, Fernandes Y, Mesquita AM, Sardessai M, Lammers JJ, Mohamed Hoesein FA, Ten Hacken NHT, van den Berge M, Galbán CJ, Siddiqui S

Abstract
Biomass and functional small airway disease http://ow.ly/gXu730abpKu.

PMID: 28828380 [PubMed]

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Predictors of intention to quit tobacco among construction site workers in Delhi, India.

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Predictors of intention to quit tobacco among construction site workers in Delhi, India.

Indian J Psychiatry. 2017 Apr-Jun;59(2):208-213

Authors: Parashar M, Singh M, Agarwalla R, Panda M, Pathak R

Abstract
BACKGROUND: Information on predictors of quitting behavior among construction site tobacco users is scarce in India. Hence, this study was conducted to assess the intention of tobacco users toward quitting and its predictors with reference to sociodemographic profile.
METHODOLOGY: A community-based, observational study was conducted on adult 172 construction site workers in a university campus of Delhi. Data were collected by an interview using the WHO-adopted, pretested, semi-structured questionnaire. Chi-square test was used for univariate analysis. Pearson's correlation coefficient and multivariate logistic regression model were used to identify the predictors.
RESULTS: Of the 172 users, 73% had intention to quit. More than half of smokers (56.5%) and 81% of smokeless tobacco users intended to quit. Majority of the tobacco users who intended to quit were literate (75.0%), started tobacco use >15 years of age (75.4%), occasional tobacco users (78.9%), and less dependent on nicotine (74.4%).
CONCLUSIONS: Suitable plan for quitting keeping in mind this vulnerable group of workers should be developed depending on the literacy, type of tobacco used, and nicotine dependency.

PMID: 28827869 [PubMed - in process]

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Lignin Valorization: Two Hybrid Biochemical Routes for the Conversion of Polymeric Lignin into Value-added Chemicals.

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Lignin Valorization: Two Hybrid Biochemical Routes for the Conversion of Polymeric Lignin into Value-added Chemicals.

Sci Rep. 2017 Aug 21;7(1):8420

Authors: Wu W, Dutta T, Varman AM, Eudes A, Manalansan B, Loqué D, Singh S

Abstract
Naturally, many aerobic organisms degrade lignin-derived aromatics through conserved intermediates including protocatechuate and catechol. Employing this microbial approach offers a potential solution for valorizing lignin into valuable chemicals for a potential lignocellulosic biorefinery and enabling bioeconomy. In this study, two hybrid biochemical routes combining lignin chemical depolymerization, plant metabolic engineering, and synthetic pathway reconstruction were demonstrated for valorizing lignin into value-added products. In the biochemical route 1, alkali lignin was chemically depolymerized into vanillin and syringate as major products, which were further bio-converted into cis, cis-muconic acid (ccMA) and pyrogallol, respectively, using engineered Escherichia coli strains. In the second biochemical route, the shikimate pathway of Tobacco plant was engineered to accumulate protocatechuate (PCA) as a soluble intermediate compound. The PCA extracted from the engineered Tobacco was further converted into ccMA using the engineered E. coli strain. This study reports a direct process for converting lignin into ccMA and pyrogallol as value-added chemicals, and more importantly demonstrates benign methods for valorization of polymeric lignin that is inherently heterogeneous and recalcitrant. Our approach also validates the promising combination of plant engineering with microbial chassis development for the production of value added and speciality chemicals.

PMID: 28827602 [PubMed - in process]

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Social Stress and Substance Use Disparities by Sexual Orientation Among High School Students.

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Social Stress and Substance Use Disparities by Sexual Orientation Among High School Students.

Am J Prev Med. 2017 Aug 18;:

Authors: Lowry R, Johns MM, Robin LE, Kann LK

Abstract
INTRODUCTION: Sexual minority youth often experience increased social stress due to prejudice, discrimination, harassment, and victimization. Increased stress may help explain the disproportionate use of substances like tobacco, alcohol, marijuana, and other illicit drug use by sexual minority youth. This study examined the effect of social stress on substance use disparities by sexual orientation among U.S. high school students.
METHODS: In 2016, data from the national 2015 Youth Risk Behavior Survey, conducted among a nationally representative sample of 15,624 U.S. high school students, were analyzed to examine the effect of school-related (threatened/injured at school, bullied at school, bullied electronically, felt unsafe at school) and non-school-related (forced sexual intercourse, early sexual debut) social stress on substance use disparities by sexual orientation, by comparing unadjusted prevalence ratios (PRs) and adjusted (for social stressors, age, sex, and race/ethnicity) prevalence ratios (APRs).
RESULTS: Unadjusted PRs reflected significantly (p<0.05 or 95% CI did not include 1.0) greater substance use among students who identified as lesbian/gay or bisexual than students who identified as heterosexual. APRs for injection drug use decreased substantially among lesbian/gay (PR=12.02 vs APR=2.14) and bisexual (PR=2.62 vs APR=1.18) students; the APR for bisexual students became nonsignificant. In addition, APRs among both lesbian/gay and bisexual students decreased substantially and were no longer statistically significant for cocaine, methamphetamine, and heroin use.
CONCLUSIONS: School-based substance use prevention programs might appropriately include strategies to reduce social stress, including policies and practices designed to provide a safe school environment and improved access to social and mental health services.

PMID: 28826950 [PubMed - as supplied by publisher]

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Ecology of the cardiovascular system: A focus on air-related environmental factors.

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Ecology of the cardiovascular system: A focus on air-related environmental factors.

Trends Cardiovasc Med. 2017 Aug 04;:

Authors: Argacha JF, Bourdrel T, van de Borne P

Abstract
Cardiology is a newcomer to environmental sciences. We aim to propose an original review of the scientific evidence regarding the effects of the environment on cardiovascular health. We report first influences of air-related environmental factors. Air temperature has a strong influence on cardiovascular mortality characterized by a V-like relationship confirming that both cold and hot periods have negative cardiovascular impacts. Furthermore, dynamic changes in temperature are likely more important than the absolute air temperature level. Cardiovascular reactions to air temperature are predominantly driven by increase in sympathetic tone. Indoor pollutants are mainly represented by smoke from cooking stoves and environmental tobacco smoke (ETS), and both are associated with increased cardiovascular mortality and morbidity. ETS is characterized by a curvilinear dose-effect relationship, showing already a significant effect even at low level of exposure and no threshold in effect appearance. Underlying ETS pathophysiology involves both effects of nicotinic stimulus on the sympathetic system and vascular oxidative stress. Smoking bans, as mitigation measures, were associated with a decrease in cardiovascular events. Long-term exposure to particulate air pollution was more recently recognized as an independent risk factor of cardiovascular mortality. Short-term increases in air pollution were also associated with an increased risk of myocardial infarction, stroke, and acute heart failure. Numerous experimental studies demonstrated that air pollution promotes a systemic vascular oxidative stress reaction followed by endothelial dysfunction, monocyte activation, and some proatherogenic changes of lipoproteins. Furthermore, air pollution favors thrombus formation as a result of increase in coagulation factors and platelet activation. Further studies are required to confirm that stricter air quality regulation or antioxidant regimen translate into some clinical benefits. In conclusion, ambient air temperature and pollution are major contributors to cardiovascular diseases. Improving air quality is now part of cardiovascular prevention.

PMID: 28826667 [PubMed - as supplied by publisher]

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Prevalence and regional correlates of road traffic injury among Chinese urban residents: A 21-city population-based study.

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Prevalence and regional correlates of road traffic injury among Chinese urban residents: A 21-city population-based study.

Traffic Inj Prev. 2017 Aug 18;18(6):623-630

Authors: Rockett IRH, Jiang S, Yang Q, Yang T, Yang XY, Peng S, Yu L

Abstract
OBJECTIVE: This study estimated the prevalence of road traffic injury among Chinese urban residents and examined individual and regional-level correlates.
METHOD: A cross-sectional multistage process was used to sample residents from 21 selected cities in China. Survey respondents reported their history of road traffic injury in the past 12 months through a community survey. Multilevel, multivariable logistic regression analysis was used to identify injury correlates.
RESULTS: Based on a retrospective 12-month reporting window, road traffic injury prevalence among urban residents was 13.2%. Prevalence of road traffic injury, by type, was 8.7, 8.7, 8.5, and 7.7% in the automobile, bicycle, motorcycle, and pedestrian categories, respectively. Multilevel analysis showed that prevalence of road traffic injury was positively associated with minority status, income, and mental health disorder score at the individual level. Regionally, road traffic injury was associated with geographic location of residence and prevalence of mental health disorders.
CONCLUSIONS: Both individual and regional-level variables were associated with road traffic injury among Chinese urban residents, a finding whose implications transcend wholesale imported generic solutions. This descriptive research demonstrates an urgent need for longitudinal studies across China on risk and protective factors, in order to inform injury etiology, surveillance, prevention, treatment, and evaluation.

PMID: 28379728 [PubMed - indexed for MEDLINE]

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New Cytotoxic Alkylated Chalcones from Fatoua villosa.

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New Cytotoxic Alkylated Chalcones from Fatoua villosa.

Chem Biodivers. 2017 Jun;14(6):

Authors: Su SY, Xue JJ, Yang GY, Lei C, Hou AJ

Abstract
Three new alkylated chalcones, villosins A - C (1 - 3), five known analogues, together with ten known coumarins, were isolated from Fatoua villosa. The structures of the new compounds were elucidated by extensive spectroscopic analysis, including 1D-, 2D-NMR, and MS data. Compounds 1 - 3 showed cytotoxicity against five kinds of human tumor cell lines (NB4, A549, SHSY5Y, PC3, and MCF7) with IC50 values ranging from 1.4 ± 0.1 to 5.7 ± 0.3 μm.

PMID: 28371315 [PubMed - indexed for MEDLINE]

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Impact of a Collective Intelligence Tailored Messaging System on Smoking Cessation: The Perspect Randomized Experiment.

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Impact of a Collective Intelligence Tailored Messaging System on Smoking Cessation: The Perspect Randomized Experiment.

J Med Internet Res. 2016 Nov 08;18(11):e285

Authors: Sadasivam RS, Borglund EM, Adams R, Marlin BM, Houston TK

Abstract
BACKGROUND: Outside health care, content tailoring is driven algorithmically using machine learning compared to the rule-based approach used in current implementations of computer-tailored health communication (CTHC) systems. A special class of machine learning systems ("recommender systems") are used to select messages by combining the collective intelligence of their users (ie, the observed and inferred preferences of users as they interact with the system) and their user profiles. However, this approach has not been adequately tested for CTHC.
OBJECTIVE: Our aim was to compare, in a randomized experiment, a standard, evidence-based, rule-based CTHC (standard CTHC) to a novel machine learning CTHC: Patient Experience Recommender System for Persuasive Communication Tailoring (PERSPeCT). We hypothesized that PERSPeCT will select messages of higher influence than our standard CTHC system. This standard CTHC was proven effective in motivating smoking cessation in a prior randomized trial of 900 smokers (OR 1.70, 95% CI 1.03-2.81).
METHODS: PERSPeCT is an innovative hybrid machine learning recommender system that selects and sends motivational messages using algorithms that learn from message ratings from 846 previous participants (explicit feedback), and the prior explicit ratings of each individual participant. Current smokers (N=120) aged 18 years or older, English speaking, with Internet access were eligible to participate. These smokers were randomized to receive either PERSPeCT (intervention, n=74) or standard CTHC tailored messages (n=46). The study was conducted between October 2014 and January 2015. By randomization, we compared daily message ratings (mean of smoker ratings each day). At 30 days, we assessed the intervention's perceived influence, 30-day cessation, and changes in readiness to quit from baseline.
RESULTS: The proportion of days when smokers agreed/strongly agreed (daily rating ≥4) that the messages influenced them to quit was significantly higher for PERSPeCT (73%, 23/30) than standard CTHC (44%, 14/30, P=.02). Among less educated smokers (n=49), this difference was even more pronounced for days strongly agree (intervention: 77%, 23/30; comparison: 23%, 7/30, P<.001). There was no significant difference in the frequency which PERSPeCT randomized smokers agreed or strongly agreed that the intervention influenced them to quit smoking (P=.07) and use nicotine replacement therapy (P=.09). Among those who completed follow-up, 36% (20/55) of PERSPeCT smokers and 32% (11/34) of the standard CTHC group stopped smoking for one day or longer (P=.70).
CONCLUSIONS: Compared to standard CTHC with proven effectiveness, PERSPeCT outperformed in terms of influence ratings and resulted in similar cessation rates.
CLINICALTRIAL: Clinicaltrials.gov NCT02200432; https://clinicaltrials.gov/ct2/show/NCT02200432 (Archived by WebCite at http://www.webcitation.org/6lEJY1KEd).

PMID: 27826134 [PubMed - indexed for MEDLINE]

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Chronic cigarette smoke exposure induces microbial and inflammatory shifts and mucin changes in the murine gut.

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Chronic cigarette smoke exposure induces microbial and inflammatory shifts and mucin changes in the murine gut.

Environ Microbiol. 2016 May;18(5):1352-63

Authors: Allais L, Kerckhof FM, Verschuere S, Bracke KR, De Smet R, Laukens D, Van den Abbeele P, De Vos M, Boon N, Brusselle GG, Cuvelier CA, Van de Wiele T

Abstract
Inflammatory bowel diseases (IBD) are complex multifactorial diseases characterized by an inappropriate host response to an altered commensal microbiome and dysfunctional mucus barrier. Cigarette smoking is the best known environmental risk factor in IBD. Here, we studied the influence of chronic smoke exposure on the gut microbiome, mucus layer composition and immune factors in conventional mice. We compared smoke-exposed with air-exposed mice (n = 12) after a smoke exposure of 24 weeks. Both Illumina sequencing (n = 6) and denaturing gradient gel electrophoresis (n = 12) showed that bacterial activity and community structure were significantly altered in the colon due to smoke exposure. Interestingly, an increase of Lachnospiraceae sp. activity in the colon was observed. Also, the mRNA expression of Muc2 and Muc3 increased in the ileum, whereas Muc4 increased in the distal colon of smoke-exposed mice (n = 6). Furthermore, we observed increased Cxcl2 and decreased Ifn-γ in the ileum, and increased Il-6 and decreased Tgf-β in the proximal colon. Tight junction gene expression remained unchanged. We infer that the modulating role of chronic smoke exposure as a latently present risk factor in the gut may be driven by the altered epithelial mucus profiles and changes in microbiome composition and immune factors.

PMID: 26033517 [PubMed - indexed for MEDLINE]

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tobacco; +21 new citations

August 22, 2017 - 6:09am

21 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results:

tobacco

These pubmed results were generated on 2017/08/22

PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.

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Effectiveness of a pragmatic school-based universal resilience intervention in reducing tobacco, alcohol and illicit substance use in a population of adolescents: cluster-randomised controlled trial.

August 20, 2017 - 7:41am

Effectiveness of a pragmatic school-based universal resilience intervention in reducing tobacco, alcohol and illicit substance use in a population of adolescents: cluster-randomised controlled trial.

BMJ Open. 2017 Aug 18;7(8):e016060

Authors: Hodder RK, Freund M, Bowman J, Wolfenden L, Campbell E, Dray J, Lecathelinais C, Oldmeadow C, Attia J, Wiggers J

Abstract
OBJECTIVES: Initiation of tobacco, alcohol and illicit substance use typically occurs during adolescence, with the school setting recommended to reduce adolescent substance use. Strengthening individual (eg, problem solving) and environmental (eg, caring relationships at school) resilience protective factors of adolescents has been suggested as a strategy for reducing substance use by adolescents; however, few studies have examined this potential. A study was conducted to investigate the effectiveness of a pragmatic school-based universal 'resilience' intervention in reducing the prevalence of tobacco, alcohol and illicit substance use, and increasing the individual and environmental protective factors of students.
DESIGN: A cluster-randomised controlled trial.
SETTING: Thirty-two Australian secondary schools (20 intervention; 12 control).
PARTICIPANTS: Cohort of grade 7 students followed-up in grade 10 (2014; aged 15-16 years).
INTERVENTION: A pragmatic intervention involving school staff selection and implementation of available programmes and resources targeting individual and environmental 'resilience' protective factors for all grade 7-10 students was implemented in schools (2012-2014). School staff were provided implementation support.
MEASUREMENTS: An online survey collected baseline and follow-up data for primary outcomes: tobacco (ever, recent) and alcohol (ever, recent, 'risk') use, and secondary outcomes: marijuana and other illicit substance use, and individual (six-factor subscales, aggregate) and environmental (three-factor subscales, aggregate) protective factor scores. Generalised and linear mixed models examined follow-up differences between groups.
RESULTS: Follow-up data from 2105 students (intervention=1261; control=844; 69% of baseline cohort) were analysed. No significant differences were found between intervention and control students for any primary (ever tobacco: OR 1.25, 95% CI 0.92 to 1.68, p=0.14; recent tobacco: OR 1.39, 95% CI 0.84 to 2.31, p=0.19; recent ever alcohol: OR 1.11, 95% CI 0.83 to 1.48, p=0.46; alcohol: OR 1.13, 95% CI 0.78 to 1.62, p=0.51; 'risk' alcohol: OR 0.98, 95% CI 0.70 to 1.36, p=0.89) or secondary outcomes (marijuana: OR 1.12, 95% CI 0.74 to 1.68, p=0.57; other illicit substance: OR 1.19, 95% CI 0.67 to 2.10, p=0.54; individual protective factors: MD=0, 95% CI -0.07 to 0.06, p=0.89; environmental protective factors: MD: -0.02, 95% CI -0.09 to 0.06, p=0.65).
CONCLUSIONS: The universally implemented pragmatic school-based intervention was not effective in reducing the prevalence of tobacco, alcohol or illicit substance use, or in increasing the protective factors of students.
TRIAL REGISTRATION: Australia and New Zealand Clinical Trials Register reference: ACTRN12611000606987.

PMID: 28821523 [PubMed - in process]

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Exploring crystalline structural variations of cellulose during pulp beating of tobacco stems.

August 20, 2017 - 7:41am

Exploring crystalline structural variations of cellulose during pulp beating of tobacco stems.

Carbohydr Polym. 2017 Oct 15;174:146-153

Authors: Zhao D, Yang F, Dai Y, Tao F, Shen Y, Duan W, Zhou X, Ma H, Tang L, Li J

Abstract
In this work, crystalline structural variations of cellulose during pulp beating of tobacco stems were characterized through X-ray diffraction (XRD) and FT-IR spectroscopy. The results showed that the correlation between the cellulose crystallinity index and the degree of beating was not a linear but an initially upward and then downward trend followed by a repeating fluctuation as a result of the beating action on amorphous regions first and then on crystalline cellulose. It was proposed that the whole beating process might be presumably divided into two phases in the case of the evolution of the crystallinity index. The crystallite sizes of 101 and 101¯ lattice planes showed an obvious fluctuation during the beating while the crystallite sizes and d-spacings from representative 002 lattice planes exhibited little change. Complementally, FT-IR characterization of cellulose structural properties further proved that the crystallinity index was highly affected by mechanical beating and the intact beating process might be divided into two stages characteristic of a first ascending and then descending tendency.

PMID: 28821053 [PubMed - in process]

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tobacco; +31 new citations

August 19, 2017 - 9:29am

31 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results:

tobacco

These pubmed results were generated on 2017/08/19

PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.

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tobacco; +28 new citations

August 18, 2017 - 6:39am

28 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results:

tobacco

These pubmed results were generated on 2017/08/18

PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.

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tobacco; +40 new citations

August 17, 2017 - 11:27am

40 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results:

tobacco

These pubmed results were generated on 2017/08/17

PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.

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tobacco; +23 new citations

August 15, 2017 - 6:39am

23 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results:

tobacco

These pubmed results were generated on 2017/08/15

PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.

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Prevalence of population smoking cessation by electronic cigarette use status in a national sample of recent smokers.

August 13, 2017 - 6:24am

Prevalence of population smoking cessation by electronic cigarette use status in a national sample of recent smokers.

Addict Behav. 2017 Aug 03;76:129-134

Authors: Giovenco DP, Delnevo CD

Abstract
INTRODUCTION: Amid decreasing rates of cigarette smoking and a rise in e-cigarette use, there is a need to understand population patterns of use to inform tobacco control efforts and evaluate whether e-cigarettes may play a role in tobacco harm reduction.
METHODS: This study merged data from the 2014 and 2015 National Health Interview Survey (NHIS) and restricted the sample to recent smokers [i.e., current smokers and former smokers who quit in 2010 or later (n=15,532)]. Log-binomial regression estimated adjusted prevalence ratios (aPR) for being quit by e-cigarette use status (i.e., daily, some day, former trier, never). All analyses controlled for factors traditionally correlated with smoking cessation.
RESULTS: A quarter of the sample (25.2%) were former smokers. The prevalence of being quit was significantly higher among daily e-cigarette users compared to those who had never used e-cigarettes [52.2% vs. 28.2%, aPR: 3.15 (2.66, 3.73)]. Those who used e-cigarettes on some days were least likely to be former smokers (12.1%). These relationships held even after accounting for making a quit attempt and use of other tobacco products.
CONCLUSIONS: Among those with a recent history of smoking, daily e-cigarette use was the strongest correlate of being quit at the time of the survey, suggesting that some smokers may have quit with frequent e-cigarette use or are using the products regularly to prevent smoking relapse. However, the low prevalence of cessation among infrequent e-cigarette users highlights the need to better understand this subgroup, including the individual factors and/or product characteristics that may inhibit cessation.

PMID: 28802179 [PubMed - as supplied by publisher]

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