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In a letter entitled “Acupuncture: What Does The Most Reliable Evidence Tell Us? An Update,” Ernst reported the headline results from Cochrane reviews on acupuncture that had been published or updated since his previous similar review in 2007. The percentage with positive results increased from 16% in 2007 to 29% in 2012.
Adrian White has a point, of course, but how relevant is it? It should not distract from my argument. Many systematic reviews of acupuncture (and other forms of Traditional Chinese Medicine) do include a multitude of methodologically weak Chinese studies. Acupuncture already has its fair share of biased reports, for example, Cummings and Kavoussi, and we should strive to reduce not increase bias. As I wrote in my Letter to the Editor, “The advantage of reviewing these studies is that they become accessible to a non-Chinese-speaking audience. The disadvantage is that neither the referees for the Cochrane Review nor its readers are likely to have access to the primary data.” My central message, however, was that acupuncture is, in most areas, not well supported by evidence. It is surprising that White thinks “The percentage with positive results has increased from 16% in 2007 to 29% in 2012.” Surely the 2012 evidence has to include all the 46 current Cochrane reviews rather than just the new ones. This would mean that the percentage is not 29% but 22%.
Abstract: Context: Breakthrough/episodic pain (BP-EP) diagnosis is often based on clinical experience, and different opinions exist, even among palliative care clinicians, about its definition and application to clinical practice.Objectives: The primary aim of this study was to assess the prevalence and clinical characteristics of BP-EP in an unselected Italian population of patients with cancer-related chronic pain, based on clinical diagnosis and on the use of an assessment tool, the Questionnaire for Intense Episodic Pain (QUDEI).Methods: A cross-sectional multicenter prevalence study of 240 consecutive cancer pain patients was carried out. The physicians participating in the study attended a training session aimed at defining and recognizing BP-EP. The QUDEI, a screening and assessment tool based on patient interview, diagnosed the presence of BP-EP in patients regularly taking analgesics for the previous three days and who had at least one pain flare in the previous 24 hours. Clinical evaluation and questionnaire application were carried out by different health care providers.Results: The estimated prevalence of BP-EP was 73% (95% confidence interval [CI]=67%, 79%) when the diagnosis was made by physicians and 66% (95% CI=60%, 72%) when the QUDEI was applied (86% agreement). When only patients with baseline pain less than or equal to six were included in the analysis, the above prevalences decreased to 67% and 60%, respectively.Conclusion: Because BP-EP is a significant phenomenon in cancer pain management, its appropriate recognition requires a more widely, internationally accepted general definition and specific validated tools for its screening and evaluation.
Abstract: Context: Few studies have examined the validity of using a single item from the Edmonton Symptom Assessment Scale (ESAS) for screening for depression.Objectives: To examine the screening performance of the single-item depression question from the ESAS in chronically ill hospitalized patients.Methods: A total of 162 chronically ill inpatients aged 65 and older completed a survey after admission that included the well-validated, 15-item Geriatric Depression Scale (GDS-15) and four single-item screening questions for depression based on the ESAS question, using two different time frames (“now” and “in the past 24 hours”) and two response categories (a 0–10 numeric rating scale [NRS] and a categorical scale: none, mild, moderate, and severe).Results: The GDS-15 categorized 20% (n=33) of participants as possibly being depressed with a score ≥6. The NRS for depression “now” achieved the highest level of sensitivity at a cutoff≥1 (68.8%), and an acceptable level of specificity was obtained at a cutoff of ≥5 (82.2%). For depression “in the past 24 hours,” a cutoff of ≥1 achieved a sensitivity of 68.8% and a cutoff of ≥7 a specificity of 80.3%. For the categorical scale, a cutoff of “none” provided the best level of sensitivity for depression “now” (65.6%) and “in the past 24 hours” (81.3%), with an acceptable level of specificity being obtained at ≥“mild” (68.8%) and ≥“moderate” (68.8%), respectively.Conclusion: These single-item measures were not effective in screening for probable depression in chronically ill patients regardless of the time frame or the response format used, but a cutoff of ≥5 or “mild” or greater did achieve sufficient specificity to raise clinical suspicion.
Abstract: Context: For patients with cancer-related pain and their physicians, routine oncology visits are an opportunity to adjust the analgesic regimen and secure better pain control. However, treatment intensification occurs haphazardly in practice.Objectives: To estimate the effect of patient-centered tailored education and coaching (TEC) on the likelihood of analgesic treatment adjustment during oncology visits, and in turn, the influence of treatment adjustment on subsequent cancer pain control, we studied patients enrolled in a randomized trial of TEC.Methods: Just before a scheduled oncology visit, 258 patients with at least moderate baseline pain received TEC or control; just after the same visit, they reported on whether the physician recommended a new pain medicine or a change in dose of an existing medicine. Pain severity and pain-related impairment were measured two, six, and 12 weeks later.Results: Patients assigned to TEC were more likely than controls to report a change in the analgesic treatment regimen (60% vs. 36%, P<0.01); significant effects persisted after adjustment for baseline pain, study site, and physician (adjusted odds ratio 2.61, 95% confidence interval 1.55, 4.40, P<0.01). In a mixed-effects repeated measures regression, analgesic change (but not TEC itself) was associated with a sustained decrease in pain severity (P<0.05).Conclusion: TEC increases the likelihood of self-reported, physician-directed adjustments in analgesic prescribing, and treatment intensification is associated with better cancer pain outcomes.
Abstract: Context: In advanced disease, the management of symptoms and lifestyle are essential for the maintenance of patients’ quality of life. Appropriate education by health professionals can help patients to better manage their disease. Although the provision of education by health professionals for patients with advanced cancer is reasonably well documented, much less is known about how health professionals facilitate education with patients with other advanced progressive diseases.Objectives: The aim of this review was to synthesize qualitative research examining health professionals’ knowledge of, attitudes toward, and ability to deliver educational interventions for symptom and disease management to patients with advanced progressive diseases other than cancer.Methods: The synthesis was conducted using meta-ethnography. Systematic searching of five electronic databases (CINAHL, Medline, PsycInfo, Web of Science Social Science Citation Index, and EMBASE) was performed. Included studies were data extracted and assessed for quality.Results: Systematic searching of four electronic databases identified 911 records; 17 studies met review inclusion criteria and underwent data extraction and quality appraisal. Three key factors were identified that influenced the delivery of education by health professionals to patients with advanced disease: capacity (to educate and aid decision making), context (of educational delivery), and timing (of education).Conclusion: Health professionals identify and acknowledge a range of factors that influence their ability to deliver education to patients with advanced disease. The types of circumstantial factors identified in this review can influence the successful delivery of educational interventions and need to be considered when such interventions are being developed.
Abstract: Specialized rural models of palliative care are greatly needed to address the challenges rural communities face in providing palliative care services and to ensure that their unique strengths and needs are considered. In late 2005, a Rural Palliative Care Program was developed to support primary care providers in delivering palliative care to patients in rural communities outside of Calgary, Alberta, Canada. The program was grounded in the needs of individual communities, incorporated integral roles for local champions, and adopted pre-existing, accepted rural structures and processes. Needs and gaps in rural palliative care service delivery were identified and prioritized. The following actions were taken to address the top six priorities: 1) more accessible palliative care education opportunities with a rural focus were provided to health care professionals; 2) linkages with rural and urban resources were strengthened and access to specialists and procedures was improved; 3) strategies were implemented to improve psychosocial support for patients and families; 4) resources were developed to facilitate rural home deaths; 5) opportunities were expanded for education and utilization of volunteers; and 6) a mobile specialist consultation team was developed to support rural health care professionals and their patients in their rural communities. In its first four years, the team consulted on 640 patients, nearly three-quarters of whom died in their rural communities. Rather than imposing an urban outreach strategy, the development of a rural-based program through respectful engagement of local providers has proven to be crucial to the success of this rural palliative care program.