Buprenorphine News Feed

Table of Contents

MedWorm Addiction Feeds - October 31, 2014 - 11:58am
Abstract Seabrook Sues Elements, Recovery Brands for Trademark Infringement Interventionist Buys Mansion, will Offer ‘Spiritual’ Care ATTC Network Launches Integration Initiative Aimed at SUDs National Council Leadership: Merger Respects SUD Concerns CRC Acquired by Acadia for $1.18 Billion 42 CFR Part 2, Buprenorphine Cap: SAMHSA Still Deliberating Coming up (Source: Alcoholism and Drug Abuse Weekly)

MedWorm Sponsor Message: MedWorm Search is coming back soon. Watch this space...

How Does Stress-Induced Activation of the Kappa Opioid System Increase Addiction Risk?

MedWorm Addiction Feeds - October 31, 2014 - 11:14am
In their article in this issue of Biological Psychiatry, Polter et al. (1) show that cold-water swim stress exposure blocks long-term potentiation of GABAergic synaptic input (LTPGABA) recorded in ventral tegmental area (VTA) dopamine neurons of male Sprague-Dawley rats. The effects of stress exposure on LTPGABA were blocked by pretreatment with the glucocorticoid antagonist RU-486 or the kappa opioid receptor (KOR) antagonist norbinaltorphimine (norBNI). When norBNI was given 4 days after stress exposure, it reversed the effects of swim stress on LTPGABA and blocked stress-induced reinstatement of cocaine self-administration. (Source: Biological Psychiatry)

More Cocaine—More Glutamate—More Addiction

MedWorm Addiction Feeds - October 31, 2014 - 11:14am
Over the last 15 years, animal models of cocaine reinforcement and reinstated drug seeking have pointed to the involvement of nucleus accumbens dopamine and glutamate neurotransmission in regulating drug intake and drug seeking, respectively (1,2). For reinstated drug seeking, evidence supporting glutamate transmission in the core subcompartment of the accumbens (NAcore) is conclusive, including: 1) α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptor antagonists prevent reinstatement of cocaine seeking; and 2) there exist enduring neuroadaptations in glutamate transmission, such as downregulated glutamate transport or upregulated calcium-permeable AMPA receptors, that if normalized prevent reinstated cocaine seeking. (Source: Biological Psychiatry)

A brief summary of the articles appearing in this issue of .

MedWorm Addiction Feeds - October 31, 2014 - 11:14am
Glück et al. (767–774) evaluated the involvement of G protein-coupled receptor kinases (GRKs) in opioid dependence and in agonist-selective μ-opioid receptor phosphorylation using GRK-deficient mice. Their findings show that μ-opioid receptor phosphorylation in vivo is regulated by agonist-selective recruitment of distinct GRK isoforms that, in turn, influence different opioid-related behaviors. These findings suggest that modulation of GRK function may serve as a potential new approach for preventing opioid addiction, while retaining the clinical benefits of opioid drugs. (Source: Biological Psychiatry)

What Tripping On Mushrooms Looks Like In The Brain

MedWorm Addiction Feeds - October 31, 2014 - 8:48am
We've all heard recreational hallucinogen users describe their trips as "consciousness expanding," and according to some new research, this poetic description may have a scientific basis. Using fMRI imaging from healthy participants who ingested psilocybin, the active ingredient in hallucinogenic "magic" mushrooms, researchers from Imperial College London found that the drug caused brain regions that are typically disconnected to communicate with each other. In a normal brain state, there's little cross-linking between different networks. But researchers found that on the psilocybin, the networks begin cross-linking all over the place. And these new connections weren't random. "It not so much that the number of connections are increased but rather that the connectivity pattern is diffe...

Methadone versus morphine for treatment of neonatal abstinence syndrome: A prospective randomized clinical trial.

Pub Med: Keyword Buprenorphine - October 31, 2014 - 7:30am
Related Articles

Methadone versus morphine for treatment of neonatal abstinence syndrome: A prospective randomized clinical trial.

J Perinatol. 2014 Oct 30;

Authors: Brown MS, Hayes MJ, Thornton LM

Abstract
Objective:Compare duration of treatment of neonatal abstinence syndrome between methadone and morphine.Study design:A prospective, double-masked, randomized trial at a single site. Randomization of methadone or morphine was stratified for maternal treatment with methadone or buprenorphine. Inclusion criteria were (i) maternal treatment with prescribed methadone or buprenorphine, (ii) withdrawal treatment criteria, (iii) adjusted gestational age ⩾35(0/7) weeks and (iv) medically stable. Primary outcome was length of opioid treatment.Result:From January 2011 through October 2012, 78 infants were eligible for the study: 41 methadone-exposed and 37 buprenorphine-exposed. Consent was obtained from 31 mothers, 13/41 (32%) methadone-treated and 18/37 (49%) buprenorphine-treated. Length of opioid treatment was significantly shorter for methadone than morphine treatment, median 14 versus 21 days (P=0.008).Conclusion:Methadone had a shorter length of neonatal withdrawal treatment compared with morphine. Owing to the smaller sample size and single site, a larger randomized study is needed.Journal of Perinatology advance online publication, 30 October 2014; doi:10.1038/jp.2014.194.

PMID: 25357093 [PubMed - as supplied by publisher]

Executive function in preschool children prenatally exposed to methadone or buprenorphine.

Pub Med: Keyword Buprenorphine - October 31, 2014 - 7:30am
Related Articles

Executive function in preschool children prenatally exposed to methadone or buprenorphine.

Child Neuropsychol. 2014 Oct 30;:1-16

Authors: Konijnenberg C, Melinder A

Abstract
Although an increasing number of children are born with prenatal methadone or buprenorphine exposure, little is still known about the potential long-term effects of these opioids. The aim of this study was to investigate executive function (EF) in children of women in opioid maintenance therapy (OMT). A total of 66 children (aged 48-57 months) participated in the study, 35 of which had histories of prenatal methadone or buprenorphine exposure. EF was measured using a battery of neuropsychological tests and the Behavior Rating Inventory of Executive Function-Preschool Version (BRIEF-P). Results showed that children of women in OMT perform lower on tasks of short-term memory and inhibition compared to nonexposed children, which was mainly associated with lower maternal education and employment rate. The OMT group scored significantly lower on all EF tasks compared to the nonexposed group, although scores fell within the average range on all measures. The development of these children should be monitored to assess for the possible problem behaviors and to promote optimal outcomes.

PMID: 25354916 [PubMed - as supplied by publisher]

Brazil study keeps Savant on wild trip to block addiction

MedWorm Addiction Feeds - October 30, 2014 - 4:35pm
To bring people down from addictive highs, a small San Carlos company is on a trip of its own. The journey of Savant HWP Inc. — the "HWP" stands for health, wellness and protection — and its experimental molecule leads from Africa to Albany, but it recently took a turn for the better in Brazil. Savant's partner in Brazil wants to develop the drug into a treatment for leishmaniasis, a potentially fatal parasitic tropical disease spread by a sand fly bite. It recently completed an early-stage… (Source: bizjournals.com Health Care:Physician Practices headlines)

MedWorm Sponsor Message: MedWorm Search is coming back soon. Watch this space...

Relative risk of injury from acute alcohol consumption: modeling the dose‐response relationship in emergency department data from 18 countries

MedWorm Addiction Feeds - October 30, 2014 - 4:20pm
ConclusionsThere is an increasing risk relationship between alcohol and injury, but risk is not uniform across gender, cause of injury, or country drinking pattern. The fractional polynomial approach is a valid and efficient approach for modeling the alcohol‐injury risk relationship. (Source: Addiction)

MedWorm Sponsor Message: MedWorm Search is coming back soon. Watch this space...

Reasons Why Your Teen Is Drinking

MedWorm Addiction Feeds - October 30, 2014 - 2:46pm
There are a plethora of factors related to why teens use substances, genetics, family environment, friends, and perhaps, boredom. Let's continue the conversation on preventing adolescent substance use problems. read more (Source: Psychology Today Addiction Center)

Somatosensory and auditory processing in opioid-exposed newborns with neonatal abstinence syndrome: a magnetoencephalographic approach.

Pub Med: Keyword Buprenorphine - October 30, 2014 - 10:30am
Related Articles

Somatosensory and auditory processing in opioid-exposed newborns with neonatal abstinence syndrome: a magnetoencephalographic approach.

J Matern Fetal Neonatal Med. 2014 Oct 29;:1-17

Authors: Kivistö K, Nevalainen P, Lauronen L, Tupola S, Pihko E, Kivitie-Kallio S

Abstract
Abstract Objective: Opioid exposure during pregnancy is a potential risk factor for the developing central nervous system of the fetus. We studied evoked responses in buprenorphine-exposed newborns who displayed neonatal abstinence syndrome (NAS) to elucidate the possible alterations in functioning of the somatosensory and auditory systems. Methods: We compared somatosensory (SEFs) and auditory evoked magnetic fields (AEFs), recorded with magnetoencephalography (MEG), of 11 prenatally buprenorphine-exposed newborns with those of 12 healthy newborns. Peak latencies, source strength, and location of SEFs or AEFs were recorded. Results: AEFs were present in all buprenorphine-exposed newborns without significant differences from those of healthy newborns. In contrast, though no group level differences in SEFs existed, at individual level the response deviated from the typical neonatal morphology in four buprenorphine-exposed newborns. Conclusions: Although buprenorphine exposure during pregnancy does not seem to cause constant deficiencies in somatosensory or auditory processing, in some newborns the typical development of somatosensory networks may be - at least transiently - disrupted.

PMID: 25354289 [PubMed - as supplied by publisher]

Livedo-like dermatitis and necrotic lesions after high-dose buprenorphine injections: a national French survey.

Pub Med: Keyword Buprenorphine - October 30, 2014 - 10:30am
Related Articles

Livedo-like dermatitis and necrotic lesions after high-dose buprenorphine injections: a national French survey.

Br J Dermatol. 2014 Oct 29;

Authors: Wainstein L, Bernier C, Gérardin M, Bouquié R, Espitia O, Mussini JM, Jolliet P, Victorri-Vigneau C

Abstract
Buprenorphine is a partial opioid agonist used as an oral maintenance treatment for opioid dependence, under the form of high-dose. The branded form of high-dose buprenorphine (HDB) -Subutex(®) - was introduced in France in 1996. Several generic drugs have been marketed ten years later. HDB has become the first oral maintenance treatment for opioid dependence in France. This article is protected by copyright. All rights reserved.

PMID: 25353069 [PubMed - as supplied by publisher]

Clinical Benchmarks Regarding Multimodal Peripheral Nerve Blocks for Postoperative Analgesia: Observations Regarding Combined Perineural Midazolam-Clonidine-Buprenorphine-Dexamethasone.

Pub Med: Keyword Buprenorphine - October 30, 2014 - 10:30am
Related Articles

Clinical Benchmarks Regarding Multimodal Peripheral Nerve Blocks for Postoperative Analgesia: Observations Regarding Combined Perineural Midazolam-Clonidine-Buprenorphine-Dexamethasone.

Pain Med. 2014 Oct 28;

Authors: Williams BA, Ibinson JW, Mangione MP, Scanlan RL, Cohen PZ

PMID: 25351887 [PubMed - as supplied by publisher]

Contesting Times

MedWorm Addiction Feeds - October 30, 2014 - 9:59am
One factor that is important in the rise of online gambling is the inter-gambler competition. Obviously there is an overlap between competitiveness and skill but they are certainly not the same. What what role does competitiveness play in gambling and problem gambling?read more (Source: Psychology Today Addiction Center)

Russian Speaking Immigrants: Drug Use, Infectious Disease and Related Health Behavior

MedWorm Addiction Feeds - October 30, 2014 - 8:44am
This article focuses on drug use, infectious disease and other factors comparing FSU males who became addicted before and after immigration to Israel. 810 drug users were surveyed in treatment centers from January 2002 to January 2012. The Addiction Severity Index and other data collection instruments were used. Those addicted before immigration have a higher level of infectious disease (i.e., HCV, HIV/AIDS and tuberculosis) and opiate use other than heroin. Those addicted after immigration reported higher rates of last 30 days sedative; cocaine and opiates other than heroin use. Injection drug use and ASI domain problem behavior were more prevalent among those addicted before immigration. Results evidence the impact of country of addiction origin on drug use patterns, infectious disease ...

Destination Hope Claims First Case of Internet Addiction Documented...

MedWorm Addiction Feeds - October 30, 2014 - 5:20am
Process addictions are the latest trend in addiction treatment centers, with more and more clients coming in for help with gambling, sex, shopping and even internet addiction.(PRWeb October 30, 2014)Read the full story at http://www.prweb.com/releases/2014/10/prweb12285158.htm (Source: PRWeb: Medical Pharmaceuticals)

Sex differences in acute hormonal and subjective response to naltrexone: the impact of menstrual cycle phase

MedWorm Addiction Feeds - October 29, 2014 - 7:00pm
The opioid receptor antagonist naltrexone is an approved pharmacotherapy in the treatment of alcohol and opioid dependence and is currently under investigation for use in other addictive behaviors (Comer et al., 2013; King et al., 2012). Several studies have reported a high degree of individual variability in treatment response to naltrexone, which has been theorized to contribute to naltrexone's modest efficacy in treating alcohol use disorders (Kranzler and Van Kirk, 2001; Ray et al., 2010; Rosner et al., 2010; Streeton and Whelan, 2001). (Source: Psychoneuroendocrinology)

Evaluating the potential impact of a reformulated version of oxycodone upon tampering, non‐adherence and diversion of opioids: the National Opioid Medications Abuse Deterrence (NOMAD) study protocol

MedWorm Addiction Feeds - October 29, 2014 - 7:00pm
DiscussionThe study's strengths lie in varied data collections; interrupted time–series analysis; and prospective cohort. To our knowledge, this is one of the most comprehensive and transparently conducted studies conducted to date of the potential impact of an opioid medication upon use, tampering and diversion. Results have the potential to inform policymakers, clinicians, consumers and researchers alike. (Source: Addiction)

The prevalence and correlates of secondary traumatic stress among alcohol and other drug workers in Australia

MedWorm Addiction Feeds - October 29, 2014 - 7:00pm
ConclusionsThe findings highlight the importance of providing adequate trauma training and clinical supervision to AOD workers in order to maintain their health and welfare and ensure optimal treatment to clients with PTSD. [Ewer PL, Teesson M, Sannibale C, Roche A, Mills KL. The prevalence and correlates of secondary traumatic stress among alcohol and other drug workers in Australia. Drug Alcohol Rev 2014] (Source: Drug and Alcohol Review)

Novel Means of Using Cigarette Packaging and Cigarettes to Communicate Health Risk and Cessation Messages: A Qualitative Study

MedWorm Addiction Feeds - October 29, 2014 - 7:00pm
This study explores novel ways in which cigarette packaging, including cigarettes, can be used to communicate health risk and cessation messages. Eight focus groups were conducted with young women smokers (N = 49), aged 16–24 years, recruited in Glasgow (Scotland). Each group was shown cigarette packs featuring Quick Response barcodes which link to stop-smoking websites if scanned by a smartphone; cigarette packs with audio messages explaining the risks associated with smoking or providing information on quitting; and cigarettes displaying the warning ‘Smoking kills’. We explored perceptions of each of these designs. Each design received a mixed response but all were perceived to have some value in communicating risk or cessation messages. Many participants were not aware of how...

Pages

Subscribe to LaraSig aggregator - Buprenorphine News Feed