Buprenorphine News Feed

Porn Comes of Age

MedWorm Addiction Feeds - July 31, 2014 - 4:00pm
A recent study from University of Cambridge reports that porn may trigger compulsion in the brain of a sex addict much the way drug paraphenalia triggers a drug addict.read more (Source: Psychology Today Addiction Center)

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Destination Hope's Drug Rehab for Women Responds to Harvard...

MedWorm Addiction Feeds - July 31, 2014 - 8:25am
Harvard study finds similarities between excessive tanning and drug addiction.(PRWeb July 31, 2014)Read the full story at http://www.prweb.com/releases/2014/07/prweb12049033.htm (Source: PRWeb: Medical Pharmaceuticals)

E-cigarette benefits outweigh risks, study says

MedWorm Addiction Feeds - July 31, 2014 - 7:08am
A study in the journal "Addiction" found that the benefits of e-cigarettes outweigh their potential health risks. Plus, new research on dementia suggests depression may be a factor. Marlie Hall reports on the day's top health news. (Source: Health News: CBSNews.com)

Feeling Like a Moral Failure

MedWorm Addiction Feeds - July 31, 2014 - 6:22am
Responsibility running riot makes us feel like moral failures.read more (Source: Psychology Today Addiction Center)

Dopamine D1 and corticotrophin releasing hormone type‐2α receptors assemble into functionally interacting complexes in living cells

MedWorm Addiction Feeds - July 31, 2014 - 4:53am
Conclusions And ImplicationsThis study indicates that D1R and CRH2αR are capable of heterodimerization in living cells. D1R/CRH2αR heteromerization might account, at least in part, for the complex physiological interactions established between dopamine and CRH in normal and pathological conditions such as addiction, representing a new potential pharmacological target. (Source: British Journal of Pharmacology)

Electronic cigarettes: review of use, content, safety, effects on smokers and potential for harm and benefit

MedWorm Addiction Feeds - July 30, 2014 - 7:00pm
ConclusionsAllowing EC to compete with cigarettes in the market‐place might decrease smoking‐related morbidity and mortality. Regulating EC as strictly as cigarettes, or even more strictly as some regulators propose, is not warranted on current evidence. Health professionals may consider advising smokers unable or unwilling to quit through other routes to switch to EC as a safer alternative to smoking and a possible pathway to complete cessation of nicotine use. (Source: Addiction)

What Does It Mean to Be "In Recovery"?

MedWorm Addiction Feeds - July 30, 2014 - 1:26pm
Many words in the addiction field have been tossed around for years without being clearly defined or even being meaningful. "Recovered," "recovery" and "being in recovery" are examples.read more (Source: Psychology Today Addiction Center)

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The Success of Prescription Drug Monitoring Programs

MedWorm Addiction Feeds - July 30, 2014 - 10:03am
The prescribing of opioid painkillers parallels the dramatic increase in number of deaths, emergency room visits, and treatment episodes due to non-medical use of controlled substances. Here is what states are doing to limit the abuse of prescription painkillers.read more (Source: Psychology Today Addiction Center)

Factors Affecting Noncompliance With Buprenorphine Maintenance Treatment.

Pub Med: Keyword Buprenorphine - July 30, 2014 - 6:30am

Factors Affecting Noncompliance With Buprenorphine Maintenance Treatment.

J Addict Med. 2014 Jul 28;

Authors: Fareed A, Eilender P, Ketchen B, Buchanan-Cummings AM, Scheinberg K, Crampton K, Nash A, Shongo-Hiango H, Drexler K

Abstract
BACKGROUND:: The current study aimed to identify risk factors for treatment noncompliance in a sample of veterans receiving buprenorphine/naloxone for an opioid use disorder.
METHODS:: Records from all patients who are currently or had previously been maintained on buprenorphine in the buprenorphine maintenance treatment program at the Atlanta VA Medical Center during the years 2006 to 2013 were evaluated. Of the 209 patients treated in the clinic between 2006 and 2013, 140 were excluded from the study because they did not have a call-back done at the time of data collection. Thus, 69 patient charts were selected for review.
RESULTS:: The multiple linear regression analysis of the predictable variables for noncompliance with the buprenorphine pill count showed that positive urine drug screen (UDS) for marijuana, benzodiazepines, and being a smoker (F = 3.08; P = 0.03) are significantly associated with noncompliance with buprenorphine pill count.Also, the multiple linear regression analysis of the predictable variables for noncompliance with the buprenorphine pill count showed that the psychiatric comorbidity independently (F = 4.88; P = 0.03) is significantly associated with noncompliance with buprenorphine pill count.
CONCLUSIONS:: Patients founds to be noncompliant were more likely to suffer from comorbid psychiatric illness. Patients who tested positive for benzodiazepines or cannabis were more likely to be noncompliant with treatment. Although the rate of noncompliance (inaccurate pill count) was high, patients were still found to be taking their prescribed buprenorphine as evidenced by positive UDS for buprenorphine/norbuprenorphine. In addition, our sample had a high rate of negative UDS screens for opioids and cocaine.

PMID: 25072677 [PubMed - as supplied by publisher]

The clinical analgesic efficacy of buprenorphine.

Pub Med: Keyword Buprenorphine - July 30, 2014 - 6:30am

The clinical analgesic efficacy of buprenorphine.

J Clin Pharm Ther. 2014 Jul 29;

Authors: Raffa RB, Haidery M, Huang HM, Kalladeen K, Lockstein DE, Ono H, Shope MJ, Sowunmi OA, Tran JK, Pergolizzi JV

Abstract
WHAT IS KNOWN AND OBJECTIVE: Based on in vitro assays and select animal models, buprenorphine is commonly called a 'partial agonist'. An implication is that it should produce less analgesic effect in humans than so-called 'full agonists' such as morphine or fentanyl. However, buprenorphine has a multimechanistic pharmacology, and thus partial agonism at a specific receptor is not particularly relevant to its overall analgesic action. We review published clinical trials that directly compared the magnitude of buprenorphine's analgesic effect to analgesics commonly considered full agonists.
COMMENT: Due to different signal transduction pathways, a drug can be a full agonist on one endpoint and a partial agonist on another. Therefore, we limited the present review to buprenorphine's analgesic effect.
WHAT IS NEW AND CONCLUSION: Twenty-four controlled clinical trials were identified, plus a case report and dose-response curve. Based on complete or comparable pain relief, in buprenorphine had full clinical analgesic efficacy in 25 of the 26 studies.

PMID: 25070601 [PubMed - as supplied by publisher]

Neonatal Abstinence Syndrome.

Pub Med: Keyword Buprenorphine - July 30, 2014 - 6:30am

Neonatal Abstinence Syndrome.

Pediatrics. 2014 Jul 28;

Authors: Kocherlakota P

Abstract
Neonatal abstinence syndrome (NAS) is a result of the sudden discontinuation of fetal exposure to substances that were used or abused by the mother during pregnancy. Withdrawal from licit or illicit substances is becoming more common among neonates in both developed and developing countries. NAS continues to be an important clinical entity throughout much of the world. NAS leads to a constellation of signs and symptoms involving multiple systems. The pathophysiology of NAS is not completely understood. Urine or meconium confirmation may assist the diagnosis and management of NAS. The Finnegan scoring system is commonly used to assess the severity of NAS; scoring can be helpful for initiating, monitoring, and terminating treatment in neonates. Nonpharmacological care is the initial treatment option, and pharmacological treatment is required if an improvement is not observed after nonpharmacological measures or if the infant develops severe withdrawal. Morphine is the most commonly used drug in the treatment of NAS secondary to opioids. An algorithmic approach to the management of infants with NAS is suggested. Breastfeeding is not contraindicated in NAS, unless the mother is taking street drugs, is involved in polydrug abuse, or is infected with HIV. Future studies are required to assess the long-term effects of NAS on children after prenatal exposure.

PMID: 25070299 [PubMed - as supplied by publisher]

A Naturalistic Comparison of the Effectiveness of Methadone and Two Sublingual Formulations of Buprenorphine on Maintenance Treatment Outcomes: Findings From a Retrospective Multisite Study.

Pub Med: Keyword Buprenorphine - July 30, 2014 - 6:30am
Related Articles

A Naturalistic Comparison of the Effectiveness of Methadone and Two Sublingual Formulations of Buprenorphine on Maintenance Treatment Outcomes: Findings From a Retrospective Multisite Study.

Exp Clin Psychopharmacol. 2014 Jul 28;

Authors: Proctor SL, Copeland AL, Kopak AM, Herschman PL, Polukhina N

Abstract
Objective: This study sought to compare the effectiveness of the 3 most commonly prescribed maintenance medications in the United States indicated for the treatment of opioid dependence in reducing illicit drug use and retaining patients in treatment. Method: Data were abstracted from electronic medical records for 3,233 patients admitted to 34 maintenance treatment facilities located throughout the United States during the period of July 1, 2012, through July 1, 2013. Patients were grouped into 1 of 3 medication categories based on their selection at intake (methadone [n = 2,738; M dosage = 64.64 mg/d, SD = 25.58], Suboxone [n = 102; M dosage = 9.75 mg/d, SD = 4.04], or Subutex [n = 393; M dosage = 12.21 mg/d, SD = 5.31]) and were studied through retrospective chart review for 6 months or until treatment discharge. Two measures of patient retention in treatment and urinalysis drug screen (UDS) findings for both opioids and various nonopioid substances comprised the study outcomes. Results: The average length of stay (LOS) in terms of days in treatment for the methadone group (M = 169.86, SE = 5.02) was significantly longer than both the Subutex (M = 69.34, SE = 23.43) and Suboxone (M = 119.35, SE = 20.82) groups. The Suboxone group evinced a significantly longer average LOS relative to the Subutex group. After adjustment for relevant covariates, patients maintained on methadone were 3.73 times (95% confidence interval [CI]= 2.82-4.92) and 2.48 times (95% CI = 1.57-3.92) more likely to be retained in treatment at 6 months than patients prescribed Subutex and Suboxone, respectively. The 6-month prevalence rates of positive UDS findings for both opioids and nonopioid substances were similar across medication groups. Conclusions: Comparable rates of illicit drug use at 6 months may be expected irrespective of maintenance medication, while increased retention may be expected for patients maintained on methadone relative to those maintained on Suboxone or Subutex. (PsycINFO Database Record (c) 2014 APA, all rights reserved).

PMID: 25069011 [PubMed - as supplied by publisher]

Buprenorphine pharmacotherapy and behavioral treatment: Comparison of outcomes among prescription opioid users, heroin users and combination users.

Pub Med: Keyword Buprenorphine - July 30, 2014 - 6:30am
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Buprenorphine pharmacotherapy and behavioral treatment: Comparison of outcomes among prescription opioid users, heroin users and combination users.

J Subst Abuse Treat. 2014 Jun 28;

Authors: Nielsen S, Hillhouse M, Mooney L, Ang A, Ling W

Abstract
Most research examining buprenorphine has been conducted with heroin users. Few studies have examined buprenorphine pharmacotherapy for prescription opioid users. Data were from a randomized controlled trial of behavioral treatment provided for 16weeks on a platform of buprenorphine pharmacotherapy and medication management. We compared heroin (H, n=54), prescription opioid (PO, n=54) and combination heroin+prescription opioid (POH, n=71) users to test the hypothesis that PO users will have better treatment outcomes compared with heroin users. The PO group provided more opioid-negative urine drug screens over the combined treatment period (PO:70%, POH:40%, H:38%, p<0.001) and at the end of the combined treatment period (PO:65%, POH:31%, H:33%, p<0.001). Retention was lowest in the H group (PO:80%, POH:65%, H:57%, p=0.039). There was no significant difference in buprenorphine dose between the groups. PO users appear to have better outcomes in buprenorphine pharmacotherapy compared to those reporting any heroin use, confirming that buprenorphine pharmacotherapy is effective in PO users.

PMID: 25065489 [PubMed - as supplied by publisher]

Preliminary survey of office-based opioid treatment practices and attitudes among psychiatrists never receiving buprenorphine training to those who received training during residency.

Pub Med: Keyword Buprenorphine - July 30, 2014 - 6:30am
Related Articles

Preliminary survey of office-based opioid treatment practices and attitudes among psychiatrists never receiving buprenorphine training to those who received training during residency.

Am J Addict. 2014 Jul 25;

Authors: Suzuki J, Connery HS, Ellison TV, Renner JA

Abstract
OBJECTIVE: To compare the characteristics, attitudes, and current prescribing practices of recently graduating psychiatrists who completed buprenorphine training during residency to those who never completed any training.
METHODS: A total of 359 psychiatrists completing residency training between 2008 and 2011 were recruited to complete an on-line survey.
RESULTS: Responses from 93 psychiatrists were included for a response rate of 25.9%. Psychiatrists completing any buprenorphine training during residency were more likely to be male and report more favorable views of OBOT with buprenorphine than compared to those who never completed any training. Twenty (38.5%) of those psychiatrists who completed training during residency reported the current prescribing of buprenorphine.
CONCLUSIONS: Completion of buprenorphine training during residency may be a factor in shaping future attitudes towards OBOT and buprenorphine prescribing practices. Further research is needed to clarify the impact of buprenorphine training during residency.
SCIENTIFIC SIGNIFICANCE: Buprenorphine training during residency training may be a contributing factor in shaping future physician attitudes towards office-based opioid treatment and buprenorphine prescribing practices. (Am J Addict 2014;XX:XX-XX).

PMID: 25065457 [PubMed - as supplied by publisher]

Exploring the relationship between cyberbullying and unnatural child death: an ecological study of twenty-four European countries

MedWorm Addiction Feeds - July 29, 2014 - 7:00pm
Conclusions: Explanations are given for the findings. We conclude that intervention programs designed to serve as precautionary measures for risk minimisation should be considered. (Source: BMC Pediatrics - Latest articles)

Barriers to accessing substance abuse treatment in Mexico: national comparative analysis by migration status

MedWorm Addiction Feeds - July 29, 2014 - 7:00pm
Conclusions: Drug dependence, gender, migration status and regional location are factors associated with access to needed treatment. Implications for health care policy to develop treatment services infrastructure and for future research are discussed in the context of ongoing drug policy reform in Mexico. (Source: Epidemiologic Perspectives and Innovations)

Karen Atkinson was addicted to cocaine at 15 and parents had NO idea

MedWorm Addiction Feeds - July 29, 2014 - 1:09pm
Karen Atkinson, 30, from Billericay, was 11 when she tried her first cigarette. By 13 she'd dabbled in cannabis, ecstasy and cocaine and at 15 was an addict. (Source: the Mail online | Health)

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High Point Treatment to use $27 million from MassDevelopment for expansion

MedWorm Addiction Feeds - July 29, 2014 - 12:14pm
High Point Treatment Center has begun the largest project in the company’s 18-year history, using $27 million in financing from the Massachusetts Development Finance Agency to expand services to addicts and the mentally ill. The project is ambitious, and includes adding 72 treatment beds and creating 220 new jobs through a $12.5 million renovation of the donated and vacant St. Luke’s Hospital in Middleborough. Funding will also refinance debt for a number of High Point facilities, and will… (Source: bizjournals.com Health Care:Hospitals headlines)

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Are You Happy With Your Life?

MedWorm Addiction Feeds - July 29, 2014 - 11:52am
We jump from thing to thing always striving for something better. But life is made up of smaller and bigger goals that are part of a larger journey.The question then is how do you stay content where you are while you aim for something else?read more (Source: Psychology Today Addiction Center)

Mindfulness with CBT May Rewire the Addicted Brain

MedWorm Addiction Feeds - July 29, 2014 - 9:48am
If addiction is written into the brain’s system of incentives and motivations, the secret to addiction recovery may be to rewrite or at least rebalance this system.read more (Source: Psychology Today Addiction Center)

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