Ventral striatum activity when watching preferred pornographic pictures is correlated with symptoms of Internet pornography addiction

MedWorm Addiction Feeds - February 7, 2016 - 6:00pm
Publication date: 1 April 2016 Source:NeuroImage, Volume 129 Author(s): Matthias Brand, Jan Snagowski, Christian Laier, Stefan Maderwald One type of Internet addiction is excessive pornography consumption, also referred to as cybersex or Internet pornography addiction. Neuroimaging studies found ventral striatum activity when participants watched explicit sexual stimuli compared to non-explicit sexual/erotic material. We now hypothesized that the ventral striatum should respond to preferred pornographic compared to non-preferred pornographic pictures and that the ventral striatum activity in this contrast should be correlated with subjective symptoms of Internet pornography addiction. We studied 19 heterosexual male participants with a picture paradigm including preferred and non-pre...

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Levels of Hair Ethyl Glucuronide in Patients with Decreased Kidney Function: Possibility of Misclassification of Social Drinkers

MedWorm Addiction Feeds - February 7, 2016 - 6:00pm
ConclusionsThis study documents an increased risk of obtaining a false‐positive diagnosis of heavy drinking among renal disease patients who are social drinkers. Interpretation of EtG levels in hair among patients with reduced kidney function must be performed with caution. The use of hair ethyl glucuronide (EtG) levels as a direct biomarker for chronic high intake of ethanol is increasing, and misclassification of alcohol consumption may have large implications. In this study, 20% (n = 8) of the individuals with decreased kidney function would have been misclassified as heavy drinkers according to the suggested EtG cutoff level for defining heavy drinking (30 pg/mg), in contrast to none of the healthy volunteers (p = 0.002). (Source: Alcoholism: Clinical and Experimental Research)

Multisensory Stop Signals Can Reduce the Disinhibiting Effects of Alcohol in Adults

MedWorm Addiction Feeds - February 7, 2016 - 6:00pm
ConclusionsThese findings identify multisensory inhibitory signals as a potentially important environmental factor that can reduce the degree to which alcohol disinhibits behavior possibly by intersensory co‐activation between the visual and auditory pathways. Multisensory stop signals reduce the degree to which alcohol impairs inhibitory control in adult drinkers. When no‐go stimuli were unimodal (i.e., visual) signals, 0.64 g/kg alcohol increased the failures to inhibit responses compared with placebo (i.e., increased disinhibition). However, this disinhibiting effect of alcohol was not observed when the no‐go stimuli were presented as multisensory (i.e., visual + aural) stop signals. This finding suggests that multisensory inhibitory signals can ameliorate the disinhibiting effe...

Early Onset Drinking Predicts Greater Level But Not Growth of Alcohol‐Induced Blackouts Beyond the Effect of Binge Drinking During Emerging Adulthood

MedWorm Addiction Feeds - February 7, 2016 - 6:00pm
ConclusionsEarly onset drinkers reported more frequent blackouts across all 3 years, indicating that early alcohol initiation predisposes those individuals to continue to experience more frequent blackouts, despite a decrease in their binge drinking. This may be due to various factors, such as altered hippocampal development and functioning resulting from early alcohol exposure. Early‐onset drinkers both experienced more frequent blackouts at Year 4 and continued to experience greater levels of blackouts over time, but they did not exhibit differential growth or change in reported blackouts, despite the fact that the time‐varying effect of binge drinking on blackouts decreased across the three years. These findings indicate that there are likely unique neurobiological factors contrib...

White House proposes $1 billion in new funding to treat opioid use disorders

MedWorm Addiction Feeds - February 7, 2016 - 6:00pm
(Source: Alcoholism and Drug Abuse Weekly)

Rosecrance project in Chicago heads to court amid some neighbors' unrest

MedWorm Addiction Feeds - February 7, 2016 - 6:00pm
(Source: Alcoholism and Drug Abuse Weekly)

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Heading into FY 2017 budget, a reminder of FY 2016 approps

MedWorm Addiction Feeds - February 7, 2016 - 6:00pm
(Source: Alcoholism and Drug Abuse Weekly)

Journal recants on marijuana‐psychosis link; oops, again

MedWorm Addiction Feeds - February 7, 2016 - 6:00pm
(Source: Alcoholism and Drug Abuse Weekly)

Briefly Noted

MedWorm Addiction Feeds - February 7, 2016 - 6:00pm
(Source: Alcoholism and Drug Abuse Weekly)

Coming Up

MedWorm Addiction Feeds - February 7, 2016 - 6:00pm
(Source: Alcoholism and Drug Abuse Weekly)

In Case You Haven't Heard

MedWorm Addiction Feeds - February 7, 2016 - 6:00pm
(Source: Alcoholism and Drug Abuse Weekly)

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The 5 Amazing Health Benefits Of Spicy Foods

MedWorm Addiction Feeds - February 7, 2016 - 7:14am
SPECIAL FROM Cayenne, jalapeno, habanero, chili—it seems like there are a million different kinds of hot peppers you can buy. And not only are they a great way to add flavor to your recipes, research shows that they may have a surprisingly positive effect on your health. Hot peppers, like jalapeños and chills, are rich in a component called capsaicin. "What we now know about capsaicin is that it has many benefits in terms of adding to the resistance to disease," says Cary Present, M.D., a medical oncologist at City of Hope hospitalin California and author ofSurviving American Medicine. "Capsaicin as a local treatment can help with pain. Eating peppers can also help improve immunity, and we know from huge study done in China that people who ate peppers a few times a week h...

Considering marijuana legalization carefully: insights for other jurisdictions from analysis for Vermont

MedWorm Addiction Feeds - February 6, 2016 - 6:00pm
ConclusionsAnalysis of possible outcomes if Vermont, USA, legalized marijuana reveal that choices about how, and not just whether, to legalize a drug can have profound consequences for the effects on health and social wellbeing, and the choices of one jurisdiction can affect the options and incentives available to other jurisdictions. (Source: Addiction)

D.C. Week: Obama Pitches $1.1 Billion to Fight Opioid Addiction

MedWorm Addiction Feeds - February 6, 2016 - 12:35pm
(MedPage Today) -- House questions infamous former Turing CEO about drug price hikes (Source: MedPage Today Allergy)

Evaluation of the influence of atipamezole on the postoperative analgesic effect of buprenorphine in cats undergoing a surgical ovariohysterectomy.

Pub Med: Keyword Buprenorphine - February 6, 2016 - 8:30am
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Evaluation of the influence of atipamezole on the postoperative analgesic effect of buprenorphine in cats undergoing a surgical ovariohysterectomy.

Vet Anaesth Analg. 2016 Feb 5;

Authors: Warne LN, Beths T, Carter JE, Whittem T, Bauquier SH

Abstract
OBJECTIVE: To evaluate the influence of atipamezole on postoperative pain scores in cats.
STUDY DESIGN: Controlled, randomized, masked clinical trial.
ANIMALS: Twelve healthy female domestic cats.
METHODS: Cats admitted for ovariohysterectomy (OVH) surgery were randomly allocated to group atipamezole (n = 6) or group saline (n = 6) and were premedicated with buprenorphine 20 μg kg(-1) intramuscularly (IM) and alfaxalone 3.0 mg kg(-1) subcutaneously (SC). Anaesthesia was induced with alfaxalone intravenously (IV) to effect and maintained with isoflurane in oxygen. Ten minutes after extubation, cats from group atipamezole received IM atipamezole (0.0375 mg kg(-1) ) whereas group saline received an equivalent volume [0.0075 mL kg(-1) (0.003 mL kg(-1) IM)] of 0.9% saline. A validated multidimensional composite scale was used to assess pain prior to premedication and postoperatively (20 minutes after extubation). If postoperative pain scores dictated, rescue analgesia consisting of buprenorphine and meloxicam were administered. Pain score comparisons were made between the two groups using a Mann-Whitney exact test. Results are reported as the median and range.
RESULTS: Preoperatively, all cats scored 0. At the postoperative pain evaluation, the pain scores from group atipamezole [16 (range, 12-20)] were not significantly different from group saline [18 (range, 15-23)] (p = 0.28). All cats required rescue analgesia post-operatively.
CONCLUSIONS AND CLINICAL RELEVANCE: Atipamezole (0.0375 mg kg(-1) IM) administration did not significantly affect the postoperative pain scores in cats after OVH. Preoperative administration of buprenorphine (20 μg kg(-1) IM) did not provide adequate postoperative analgesia for feline OVH.

PMID: 26849034 [PubMed - as supplied by publisher]

Project ECHO: A new model for educating primary care providers about treatment of substance use disorders.

Pub Med: Keyword Buprenorphine - February 6, 2016 - 8:30am
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Project ECHO: A new model for educating primary care providers about treatment of substance use disorders.

Subst Abus. 2016 Feb 5;:0

Authors: Komaromy M, Duhigg D, Metcalf A, Carlson C, Kalishman S, Hayes L, Burke T, Thornton K, Arora S

Abstract
BACKGROUND: Project ECHO trains and mentors primary care providers (PCPs) in the care of patients with complex conditions. ECHO is a distance education model that connects specialists with numerous PCPs via simultaneous video link for the purpose of facilitating case-based learning. We describe a teleECHO clinic based at the University of New Mexico Health Sciences Center that is focused on treatment of substance use disorders (SUDs) and behavioral health disorders.
METHODS: Since 2005, specialists in treatment of SUDs and behavioral health disorders at Project ECHO have offered a weekly 2-hour Integrated Addictions and Psychiatry (IAP) TeleECHO Clinic focused on supporting PCP evaluation and treatment of SUDs and behavioral health disorders. We tabulate the number of teleECHO clinic sessions, participants, and CME/CEU credits provided annually. This teleECHO clinic has also been used to recruit physicians to participate in DATA-2000 buprenorphine waiver trainings. Using a database of the practice location of physicians who received the buprenorphine waiver since 2002, we calculate the number of waivered physicians per capita in US states. We evaluate the increase in waivered physicians practicing in underserved areas in NM compared to the rest of the US.
RESULTS: Since 2008, approximately 950 patient cases have been presented during the teleECHO clinic, and more than 9000 hours of CME/CEU have been awarded. Opioids are the substances discussed most commonly (31%), followed by Alcohol (21%) and Cannabis (12%). New Mexico is near the top among US states in DATA-2000 buprenorphine waivered physicians per capita, and has had much more rapid growth in waivered physicians practicing in traditionally-underserved areas compared with the rest of the US since the initiation of the teleECHO clinic focused on SUDs in 2005.
CONCLUSION: The ECHO model provides an opportunity to promote expansion of access to treatment for opioid use disorder and other SUDs, particularly in underserved areas.

PMID: 26848803 [PubMed - as supplied by publisher]

Wernicke’s Encephalopathy in Crack-Cocaine Addiction

MedWorm Addiction Feeds - February 5, 2016 - 6:00pm
Crack-cocaine addiction is associated with a variety of conditions that increase risk of thiamine deficiency and Wernicke’s encephalopathy. (Source: Medical Hypotheses)

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Detection of 3-methylmethcathinone and its metabolites 3-methylephedrine and 3-methylnorephedrine in pubic hair samples by liquid chromatography–high resolution/high accuracy Orbitrap mass spectrometry

MedWorm Addiction Feeds - February 5, 2016 - 6:00pm
Amphetamine-related designer drugs (mainly phenethylamines, tryptamines, piperazines and cathinones), as well as synthetic cannabinoids, represent the new psychoactive substances (NPS) that most frequently have appeared for some years now on the recreational drug market. According to the European Monitoring Centre for Drugs and Drug Addiction (EMCDDA), there has been a seven-fold increase in reported seizures of NPS between 2008 and 2013 in Europe, and more than 450 NPS are currently being monitored by the EMCDDA [1]. (Source: Forensic Science International)

Validity and reliability assessment of the Brazilian version of the game addiction scale (GAS)

MedWorm Addiction Feeds - February 5, 2016 - 6:00pm
This study assessed the convergent validity and reliability of the GAS according to measures of internal consistency and test–retest stability. (Source: Comprehensive Psychiatry)

Network analysis of substance abuse and dependence symptoms

MedWorm Addiction Feeds - February 5, 2016 - 6:00pm
Drug abuse and dependence is a common and increasing worldwide public health concern (World Health Organization, 2010). In the US, life-time prevalence estimates of substance use disorders (SUD) range from 2–3% for illicit substances to 8% for alcohol use, and 12-month rates of substance abuse or dependence increase from 7% to 20% during adolescence (Merikangas and McClair, 2012). (Source: Drug and Alcohol Dependence)

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