Buprenorphine News Feed

Editorial Board

MedWorm Addiction Feeds - 12 hours 30 min ago
(Source: Journal of Substance Abuse Treatment)

MedWorm Sponsor Message: Find the best Christmas Sales, Boxing Day Sales and January Sales here.

Contents

MedWorm Addiction Feeds - 12 hours 30 min ago
(Source: Journal of Substance Abuse Treatment)

RECENT Cocaine USE is a SIGNIFICANT risk factor for sudden cardiovascular death in 15‐49 years old SUBJECTS. A forensic case‐control study

MedWorm Addiction Feeds - 12 hours 33 min ago
ConclusionsRecent use of cocaine is significantly associated with an increased risk for sudden cardiovascular death in people 15‐49 years old. (Source: Addiction)

Intravenous sufentanil-midazolam versus sevoflurane anaesthesia in medetomidine pre-medicated Himalayan rabbits undergoing ovariohysterectomy.

Pub Med: Keyword Buprenorphine - 12 hours 43 min ago

Intravenous sufentanil-midazolam versus sevoflurane anaesthesia in medetomidine pre-medicated Himalayan rabbits undergoing ovariohysterectomy.

Vet Anaesth Analg. 2014 Jul 21;

Authors: Hedenqvist P, Jensen-Waern M, Fahlman A, Hagman R, Edner A

Abstract
OBJECTIVE: To compare physiological effects of sufentanil-midazolam with sevoflurane for surgical anaesthesia in medetomidine premedicated rabbits.
STUDY DESIGN: Prospective, randomized controlled experimental study.
ANIMALS: Eighteen female Himalayan rabbits, weight 2.1 ± 0.1 kg.
METHODS: Premedication with 0.1 mg kg(-1) medetomidine and 5 mg kg(-1) carprofen subcutaneously, was followed by intravenous anaesthetic induction with sufentanil (2.3 μg mL(-1) ) and midazolam (0.45 mg mL(-1) ). After endotracheal intubation, anaesthesia was maintained with sufentanil-midazolam (n = 9) or sevoflurane (n = 9). Ovariohysterectomy was performed. Intermittent positive pressure ventilation was performed as required. Physiological variables were studied perioperatively. Group means of physiologic data were generated for different anaesthetic periods. Data were compared for changes from sedation, and between groups by anova. Post-operatively, 0.05 mg kg(-1) buprenorphine was administered once and 5 mg kg(-1) carprofen once daily for 2-3 days. Rabbits were examined and weighed daily until one week after surgery.
RESULTS: Smooth induction of anaesthesia was achieved within 5 minutes. Sufentanil and midazolam doses were 0.5 μg kg(-1) and 0.1 mg kg(-1) , during induction and 3.9 μg kg(-1)  hour(-1) and 0.8 mg kg(-1)  hour(-1) during surgery, respectively. End-tidal sevoflurane concentration was 2.1% during surgery. Assisted ventilation was required in nine rabbits receiving sufentanil-midazolam and four receiving sevoflurane. There were no differences between groups in physiologic data other than arterial carbon dioxide. In rabbits receiving sevoflurane, mean arterial pressure decreased pre-surgical intervention, heart rate increased 25% during and after surgery and body weight decreased 4% post-operatively. Post-operative problems sometimes resulted from catheterization of the ear artery.
CONCLUSION: Sevoflurane and sufentanil-midazolam provided surgical anaesthesia of similar quality. Arterial blood pressure was sustained during sufentanil-midazolam anaesthesia and rabbits receiving sevoflurane lost body weight following ovariohysterectomy. Mechanical ventilation was required with both anaesthetic regimens.
CLINICAL RELEVANCE: Anaesthesia with sufentanil-midazolam in medetomidine premedicated healthy rabbits is useful in the clinical and the research setting, as an alternative to sevoflurane.

PMID: 25041686 [PubMed - as supplied by publisher]

Antinociceptive effect of buprenorphine and evaluation of the nociceptive withdrawal reflex in foals.

Pub Med: Keyword Buprenorphine - 12 hours 43 min ago

Antinociceptive effect of buprenorphine and evaluation of the nociceptive withdrawal reflex in foals.

Vet Anaesth Analg. 2014 Jul 21;

Authors: Risberg AI, Spadavecchia C, Ranheim B, Hendrickson EH, Lervik A, Haga HA

Abstract
OBJECTIVE: To elicit and evaluate the NWR (nociceptive withdrawal reflex) in 2 and 11 day old foals, to investigate if buprenorphine causes antinociception and determine if the NWR response changes with increasing age. The effect of buprenorphine on behaviour was also evaluated.
STUDY DESIGN: Prospective, experimental cross-over trial.
ANIMALS: Nine Norwegian Fjord research foals.
METHODS: Buprenorphine, 10 μg kg(-1) was administered intramuscularly (IM) to the same foal at 2 days and at 11 days of age. The NWR and the effect of buprenorphine were evaluated by electromyograms recorded from the left deltoid muscle following electrical stimulation of the left lateral palmar nerve at the level of the pastern. Mentation, locomotor activity and respiratory rate were recorded before and after buprenorphine administration.
RESULTS: We were able to evoke the NWR and temporal summation in foals using this model. Buprenorphine decreased the root mean square amplitude following single electrical stimulation (p < 0.001) in both age groups, and increased the NWR threshold following single electrical stimulation in 2 day old foals (p = 0.0012). Repeated electrical stimulation at 2 Hz was more effective to elicit temporal summation compared to 5 Hz (p < 0.001). No effect of age upon the NWR threshold was found (p = 0.34). Sedation when left undisturbed (11 occasions), increased locomotor activity when handled (9 occasions) and tachypnea (13 occasions) were common side-effects of buprenorphine.
CONCLUSION AND CLINICAL RELEVANCE: These findings indicate that buprenorphine has antinociceptive effect in foals. Opioid side effects often recognized in adult horses also occur in foals.

PMID: 25041444 [PubMed - as supplied by publisher]

The Impact of Prior Authorization on Buprenorphine Dose, Relapse Rates, and Cost for Massachusetts Medicaid Beneficiaries with Opioid Dependence.

Pub Med: Keyword Buprenorphine - 12 hours 43 min ago

The Impact of Prior Authorization on Buprenorphine Dose, Relapse Rates, and Cost for Massachusetts Medicaid Beneficiaries with Opioid Dependence.

Health Serv Res. 2014 Jul 9;

Authors: Clark RE, Baxter JD, Barton BA, Aweh G, O'Connell E, Fisher WH

Abstract
OBJECTIVE: To assess the impact of a 2008 dose-based prior authorization policy for Massachusetts Medicaid beneficiaries using buprenorphine + naloxone for opioid addiction treatment. Doses higher than 16 mg required progressively more frequent authorizations.
DATA SOURCES: Mediciaid claims for 2007 and 2008 linked with Department of Public Health (DPH) service records.
STUDY DESIGN: We conducted time series for all buprenorphine users and a longitudinal cohort analysis of 2,049 individuals who began buprenorphine treatment in 2007. Outcome measures included use of relapse-related services, health care expenditures per person, and buprenorphine expenditures.
DATA COLLECTION/EXTRACTION METHODS: We used ICD-9 codes and National Drug Codes to identify individuals with opioid dependence who filled prescriptions for buprenorphine. Medicaid and DPH data were linked with individual identifiers.
PRINCIPAL FINDINGS: Individuals using doses >24 mg decreased from 16.5 to 4.1 percent. Relapses increased temporarily for some users but returned to previous levels within 3 months. Buprenorphine expenditures decreased but total expenditures did not change significantly.
CONCLUSION: Prior authorization policies strategically targeted by dose level appear to successfully reduce use of higher than recommended buprenorphine doses. Savings from these policies are modest and may be accompanied by brief increases in relapse rates. Lower doses may decrease diversion of buprenorphine.

PMID: 25040021 [PubMed - as supplied by publisher]

The Internet Addiction Test: Assessing its psychometric properties in Bangladeshi culture.

MedWorm Addiction Feeds - 13 hours 2 min ago
Authors: Karim AK, Nigar N Abstract There is growing importance of the Internet Addiction Test (IAT) in Internet addiction research around the world. Since the development of the IAT (Young, 1996, 1998), a number of validation studies have been done in various cultures. The aim of this study was to translate the instrument into Bangla and validate in Bangladeshi culture, a culture vulnerable to Internet addiction. A total of 177 Internet users (77 females and 100 males) participated in the study. Exploratory factor analysis (EFA) of the data from 172 participants (who provided complete responses) identified a four factor structure of the IAT with 18 items. The four factors namely 'Neglect of duty', 'Online dependence', 'Virtual fantasies', and 'Privacy and self-defense' together ex...

Hazardous birthday drinking among young people: population‐based impacts on emergency department and in‐patient hospital admissions

MedWorm Addiction Feeds - July 21, 2014 - 7:00pm
ConclusionsThere appears to be an increase in alcohol‐related adverse events from drinking around the time of one's birthday among young adults in Canada. (Source: Addiction)

MedWorm Sponsor Message: Find the best Christmas Sales, Boxing Day Sales and January Sales here.

A Noise That Annoys

MedWorm Addiction Feeds - July 21, 2014 - 4:22am
‘Exploding Head Syndrome’ (EHS) is condition that was first reported almost 100 years ago. EHS is known to be a type of hypnagogic auditory hallucination where the person experiences a very sudden and brief loud (but usually painless) noise originating from inside their head for a fraction of a second. But what do we know about it and how can it be treated?read more (Source: Psychology Today Addiction Center)

MedWorm Sponsor Message: Find the best Christmas Sales, Boxing Day Sales and January Sales here.

International team sheds new light on biology underlying schizophrenia

MedWorm Addiction Feeds - July 20, 2014 - 11:00pm
(Centre for Addiction and Mental Health) As part of a multinational, collaborative effort, researchers from Canada's Centre for Addiction and Mental Health have helped identify over 100 locations in the human genome associated with the risk of developing schizophrenia. The findings, published online in Nature, point to biological mechanisms and pathways that may underlie schizophrenia, and could lead to new approaches to treating the disorder, which has seen little innovation in drug development in more than 60 years. (Source: EurekAlert! - Medicine and Health)

Genetic variation in personality traits explains genetic overlap between borderline personality features and substance use disorders

MedWorm Addiction Feeds - July 20, 2014 - 7:00pm
ConclusionsBoth genetic and individual‐specific environmental factors contribute to comorbidity between borderline personality features and substance use disorders. A substantial proportion of this comorbidity can be attributed to variation in normal personality traits, particularly Neuroticism. (Source: Addiction)

MedWorm Sponsor Message: Find the best Christmas Sales, Boxing Day Sales and January Sales here.

Is Smoking Cessation Associated with Worse Comorbid Substance Use Outcomes among Homeless Adults?

MedWorm Addiction Feeds - July 20, 2014 - 7:00pm
ConclusionsIn homeless smokers, achieving smoking abstinence may be associated with a reduction in alcohol consumption but appears not to be associated with a substantial change in other drug use. (Source: Addiction)

Role of smoking in regional variation in mortality in Poland

MedWorm Addiction Feeds - July 20, 2014 - 7:00pm
ConclusionsDifferences in past smoking behaviour may largely explain the regional differences in all‐cause mortality existing in 2008–10 in Poland, and its trends since 1991–1993. (Source: Addiction)

Favourite alcohol advertisements and binge drinking among adolescents: a cross‐cultural cohort study

MedWorm Addiction Feeds - July 20, 2014 - 7:00pm
ConclusionsAmong European adolescents naming a favourite alcohol advertisement was associated with increased likelihood of initiating binge drinking during 1‐year follow‐up, suggesting a relationship between alcohol marketing receptivity and adolescent binge drinking. (Source: Addiction)

Letter to the Editor

MedWorm Addiction Feeds - July 20, 2014 - 7:00pm
(Source: Addiction)

The Choice is Yours

MedWorm Addiction Feeds - July 20, 2014 - 5:32pm
Can a simple change in perspective really help us reach what sometimes seem like unattainable goals? The answer, like the future achievements, begins with you and a quiet choice to shift your point of view.read more (Source: Psychology Today Food and Diet Center)

MedWorm Sponsor Message: Find the best Christmas Sales, Boxing Day Sales and January Sales here.

Internet Addiction-–Sign of a Medical Problem?

MedWorm Addiction Feeds - July 20, 2014 - 1:47pm
Needles in the haystack of Internet Addiction–two dramatic medical conditions that can drive Internet Addiction are discussed in this article. read more (Source: Psychology Today Sex Center)

MedWorm Sponsor Message: Find the best Christmas Sales, Boxing Day Sales and January Sales here.

Internet Addiction--Sign of a Medical Problem?

MedWorm Addiction Feeds - July 20, 2014 - 1:47pm
Needles in the Haystack of Internet Addiction----Two dramatic medical conditions that can drive Internet addiction are discussed in this article. read more (Source: Psychology Today Addiction Center)

MedWorm Sponsor Message: Find the best Christmas Sales, Boxing Day Sales and January Sales here.

Altering impulsive decision making with an acceptance-based procedure.

MedWorm Addiction Feeds - July 20, 2014 - 2:20am
Authors: Morrison KL, Madden GJ, Odum AL, Friedel JE, Twohig MP Abstract Delay discounting is one facet of impulsive decision making and involves subjectively devaluing a delayed outcome. Steeply discounting delayed rewards is correlated with substance abuse and other problematic behaviors. To the extent that steep delay discounting underlies these clinical disorders, it would be advantageous to find psychosocial avenues for reducing delay discounting. Acceptance-based interventions may prove useful as they may help to decrease the distress that arises while waiting for a delayed outcome. The current study was conducted to determine if a 60-90minute acceptance-based training would change delay discounting rates among 30 undergraduate university students in comparison to a waitlist ...

MedWorm Sponsor Message: Find the best Christmas Sales, Boxing Day Sales and January Sales here.

Sexual Enhancement Products for Sale Online: Raising Awareness of the Psychoactive Effects of Yohimbine, Maca, Horny Goat Weed, and Ginkgo biloba.

MedWorm Addiction Feeds - July 19, 2014 - 2:50pm
Conclusions. Uncontrolled availability of sexual enhancement products that contain potentially harmful substances is a major public health concern. The possible impact on population health, particularly among subjects with psychiatric disorders, usually at risk for sexual dysfunction, may be significant. This new trend needs to be extensively studied and monitored. PMID: 25025070 [PubMed - as supplied by publisher] (Source: Biomed Res)

Pages

Subscribe to LaraSig aggregator - Buprenorphine News Feed